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06346


Physik (Master) Wintersemester 2011/2012
06346 Theoretische Biophysik [V]
   
Dozent Goychuk I.
Dauer 4 SWS
Studiensemester 0
Schein Ja (Mündl.Prüfung; 8 LP)
Termin Di, 12:15-13:45 u. Fr, 10:00-11:30, 2003/T
Beginn 18.10.2011
Inhalt 1. Cell structure and organization. Molecules of life, structure-function relations. Importance of dynamics, spatial and time scales.

2. Molecular forces in biological structures. Entropic forces and importance of electrostatics. Energy scales. Molecular dynamics and visualization.

3. Global transitions in proteins. Two-state thermodynamical model and Arrhenius kinetics.

4. Biochemical reactions: macroscopic enzyme kinetics and stochastic effects in real cells. Free energy transduction and biochemical cycle kinetics.

5. Gene-protein circuits (genetic regulation), genetic switches and oscillators.

6. Transmembrane transport: ion channels, pumps, and transporters.

7. Excitable membranes: Hodgkin-Huxley model and bottom-up approach

8. Molecular motors as macromolecular Brownian machines.

Begleitend 06347
Vorkenntnisse Mechanik, Elektrodynamik, Thermodynamik und Statistische Physik

Literatur 1. P. Nelson, Biological Physics: Energy, Information, Life (Freeman, New York, 2004).

2. M. B. Jackson, Molecular and Cellular Biophysics (Cambridge University Press, 2006).

3. T. L. Hill, Free Energy Transduction and Biochemical Cycle Kinetics (Dover Publications, 2004).

4. J. Keener and J. Sneyd, Mathematical Physiology (Springer, New York, 2001).

5. R. Nossal and H. Lecar, Molecular and Cell Biophysics (Addison-Wesley, Redwood City, 1991).

6. T. D. Pollard, W. C. Earnshaw, and J. Lippincott-Schwartz, Cell Biology, second edition (Spektrum Verlag, 2007).

7. P. Atkins and J. de Paula, Physical Chemistry, 8th ed. (Oxford University Press, Oxford, 2006).

Weitere Informationen http://www.physik.uni-augsburg.de/~igor/biophys.html